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2008

ERECTILE DYSFUNCTION NEWS

2008-12-25

Levitra - a step ahead of Viagra

In reality, most people need 50mg or 100mg dosage of Viagra tablets for better results. 25mg Viagra does not seem to work for most. Whereas, Levitra comes in considerably dosage forms of 2.5mg, 5mg, 10mg, and 20mg, with 10mg dose working effectively for most people.

Levitra is also a step ahead of Viagra as lesser dosage means lesser probability of side effects. In this sense, you might experience fewer side effects with Levitra and you can wipe out the chances of experiencing the nasty side effects of Viagra.

If you are allergic to the active ingredient sildenafil found in Viagra or any other active ingredient, Levitra could be your answer. So find out more about web design the ‘not so popular’ yet an effective impotence medicine. Levitra may be the manna from heaven for you even if Viagra wasn’t.

What is the normal recommended dosage?

The suggested dose of levitra is to start with 10mg, and to adjust the strength depending on the results. However, the doctor may change your selection if he/she feels that based on your medical conditions.

How effective is Levitra?

4,400 men with impotence participated in over 50 trials to test the effectiveness of Levitra. The studies revealed a clinically meaningful and statistically significant result compared with placebo.

A further four independent trials were done for Levitra in the US. Two trials were conducted in the general impotence population and two in special groups (patients with diabetes; and post-prostatectomy patients). web design results for all four trials were just as significant: Levitra significantly improved the rates of achieving an erection compared to placebo (80% for Levitra 20mg, compared to a 52% response in the placebo).

Who should not take Levitra?

Levitra is only for male patients with impotence; it is not for children or women. Before you start treatment of Levitra, be sure to ask your family doctor if your heart is healthy enough, as it can alter blood pressure.

Levitra is never to be used in conjunction with nitrate drugs. The combination of Levitra and nitrates can make your blood pressure suddenly drop to unsafe levels. Nitrates are found in many prescription medications that are used to treat angina (chest pain due to heart disease), including:

• Nitroglycerin(sprays, ointments, skin patches or pastes, and tablets that are swallowed or dissolved in the mouth)

• Isosorbide mononitrate and isosorbide dinitrate (tablets that are swallowed, chewed, or dissolved in the mouth)

Nitrates are also found in recreational drugs such as amyl nitrate or nitrite (’poppers’). If you are not sure if any of your medications contain nitrates, or if you do not understand what nitrates are, contact Meds4all.

2008-12-10

Cialis treats ED in men with prostate problems

Tadalafil provides consistent improvements for erectile function in men with lower urinary-tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) with a history of erectile dysfunction (ED), and for prostate symptom scores in these patients with or without a history of ED, according to research presented at the Joint Congress of the European and International Societies for Sexual Medicine (ESSM-ISSM).

Gregory Broderick, MD, Mayo Clinic, Jacksonville, Florida, presented results here on December 8 from 2 randomised, double-blind, placebo-controlled, phase 3 studies that shared the same study population. Dr. Broderick was lead author for the study of symptom reduction in BPH, and he also described a second study on ED in men with LUTS on behalf of Hartmut Porst, MD, and colleagues.

The symptoms of men with BPH who suffer from LUTS include problems with urinary frequency, urgency, intermittency, nocturia, straining, incomplete emptying, and a weak urinary stream, said Dr. Broderick. "The question has recently been raised: Could PDE5 inhibitors be of utility in lower urinary-tract symptoms, which men complain of with increasing frequency as they age?"

ED is highly prevalent in aging men, with a frequent association in the same men seen for BPH and LUTS. The researchers in both studies thus investigated possible common pathophysiological mechanisms through the use of tadalafil.

The objectives of the multicentre 12-week studies were similar. In Dr. Broderick's study the objective was to evaluate the effect of once-daily tadalafil on ED in sexually active men with moderate to severe LUTS secondary to BPH. In Dr. Porst's study, the objective was to investigate tadalafil responses in these men with or without a history of ED in a post-hoc analysis of International Prostate Symptom Score (IPSS) total scores.

Eligible patients were aged 45 years or older and had a history of LUTS secondary to BHP for over 6 months. This included IPSS scores of 13 or greater and a peak urinary flow of 4 to 15 mL/second, with or without a history of ED.

In all, 1,056 patients were randomised to once-daily placebo (n = 211) or tadalafil for 12 weeks. The tadalafil doses were randomised as follows: 2.5 mg (n = 208), 5.0 mg (n = 212), 10 mg (n = 216), or 20 mg (n = 209). The ED population was 581 patients, distributed as 65% to 69% of these treatment groups (n = 115, 113, 117, 120, 116, respectively).

The main patient baseline characteristics were similar across treatment groups for both the total patient population and the ED group. Between the 2 studies, these characteristics were as follows: mean age of 62 to 63 years; mean BMI of 28 to 29 kg/m2; LUTS severity of 65% to 71% moderate; LUTS duration of 79% to 88% over 1 year; and ED severity, where appropriate, of 48% to 58% moderate, 13% to 18% severe.

Within the ED group, at week 12, the baseline International Index of Erectile Function-Erectile Function (IIEF-EF) domain scores (17.3, 17.4, 15.3, 17.2, 16.3, respectively) showed significant improvements over those of placebo patients (+2.0) for all tadalafil treatment groups (+5.4, +6.8, +7.9, +8.2, respectively; P < .001 for all). These improvements became evident within 4 weeks of treatment initiation and were independent of baseline LUTS severity.

Across the patient population, the post-hoc analysis of IPSS total scores showed improvements over baseline for patients both with no history of ED (-2.4, -3.2, -5.3, -5.1, -4-5, respectively) and with history of ED (-2.4, -4.3, -4.8, -5.3, -5.6, respectively). Significance of treatment changes over placebo were reached at tadalafil doses of 5 mg daily and higher (P < .05).

Treatment-emergent adverse events in the trials showed small increases over placebo towards higher tadalafil treatments (placebo/20 mg), including for back pain (0.5%/5.7%), dyspepsia (0.0%/4.8%), headache (2.8%/3.3%), myalgia (0.0%/2.9%), nasopharyngitis (0.9%/2.4%), and diarrhoea (1.4%/2.4%).

"If you should come into the doctor complaining of mild to moderate ED and mild to moderate lower urinary-tract symptoms," noted Dr. Broderick, "you are likely to see an improvement in both complaints [with tadalafil]." He added that tadalafil provides the ability to treat the 2 conditions in the aging male with 1 tablet, quite effectively, for the first time.

2008-12-12

10 years of Viagra: What the blue pill couldn't cure

Before middle-aged men started singing "Viva Viagra" in TV ads, before former Sen. Bob Dole appeared in its commercials in the '90s, before the blue pill with a funny name entered the public lexicon, impotence was hush-hush.

Viagra entered the market 10 years ago, bringing once taboo subjects like erectile dysfunction out in the open.

Viagra entered the market 10 years ago, bringing once taboo subjects like erectile dysfunction out in the open.

Now there's no getting away from it.

In-boxes are clogged daily with spam mail promising cheap and instant manliness delivered fast and in bulk. Couples exchange amorous, come-hither looks followed by a lengthy recitation of side effects on TV ads. The pill helped more than 25 million men get their groove back and blasted the topic of erectile dysfunction into the open.

"It's like the nuclear explosion," said Dr. Irwin Goldstein, director of Sexual Medicine at Alvarado Hospital in San Diego, California. "It created sexual medicine. It allowed the taboo to be broken."

Since the diamond-shaped blue pill debuted 10 years ago, it has become embedded in the public psyche, late-night television jokes and urologists' offices.

"It is one of the revolutionary steps in sexual health," said Dr. Ira Sharlip, spokesman for the American Urological Association. "It ranks with the changes in cultural attitudes about sexuality that were started by [Sigmund] Freud, continued by [William] Masters and [Virginia] Johnson, the two researchers in the '60s, and the work that [Alfred] Kinsey did in the '40s.

"These were the huge steps in the development of our understanding of human sexuality and cultural attitudes of sex."

Men seldom talked about their bedroom troubles before the U.S. Food and Drug Administration approved Viagra as the first oral medication for erectile dysfunction in 1998.

"We lamented the fact that the men had so much shame about erectile dysfunction, how rarely anyone came for medical attention," said Dr. Abraham Morgentaler, an associate clinical professor of urology at Harvard Medical School.

Penis injections and vacuum pumps were available, but these treatments weren't appealing. Men with medical conditions such as diabetes, prostate cancer, hyper cholesterol, endocrinological and cardiovascular problems weren't able to enjoy sex, Goldstein said.

"People who couldn't enjoy intimacy before have been given a second life...." he said. "We have had a better life because of it."

Viagra increases blood flow to the penis, enabling a man to have an erection. The drug does not induce desire and works when the man is sexually aroused, according to Pfizer, the makers of Viagra.

Urologists heard from patients who had tried the pill that Viagra made them feel as if they were 20-year-olds again. Anti-impotence drugs Levitra and Cialis have come along since.

"Along with the birth control pill in the '60s, this pill really changed people, society and medicine," Goldstein said. "It changed the patient-physician relationship. You can walk in and ask about sexual functions. It was a major taboo at some point."

Dr. Gerald Melchiode, a Texas psychiatrist, agreed that the pill has helped men open up about their sexual health, but finds the commercials a bit much.

"I've never run across men singing about their impotency," he said.

Since Viagra's appearance on the market, the dialogue about sexual dysfunctions has helped doctors identify other health problems in their patients, doctors say.

"You always hear someone drops dead,"said Dr. Chris Steidle, a urologist who wrote the book "Sex and the Heart." "It's not sudden death if you couldn't get an erection. It's a symptom of a heart condition. You wouldn't ignore a stroke, but you would ignore erectile dysfunction -- it's a significant symptom."

The man's penis is like "the tip of the iceberg" or "the canary in the mines," which serve as an indicator of overall health, Morgentaler said.

"There's now good evidence that shows that men with ED who have no other symptoms of anything are at increased risk for heart attacks and strokes," he said. Thousands of studies have been conducted on Viagra. "The pill that thrills" is also being studied to see whether it gives athletes an edge in competition. It's been studied to see whether it helps women with their sexual health. Despite the deluge of attention, Viagra doesn't work for about 25 percent to 35 percent of men with erectile dysfunction.

For others, it has revitalized and strained marriages. Experts say Viagra gave a window into the psyche of men and women.

Some complain that sex should be spontaneous and that popping a pill ruins the romance. Eating food decreases the potency of Viagra, and some say the pill forces them to go on a schedule. Another complaint: Having to use Viagra makes a spouse or partner feel undesirable.

"Sometimes their spouse personalizes it," said Melchiode. "Why does he have to take this pill? Aren't I attractive enough? Aren't I sexy enough for him? That's not unusual for the partner."

Even when Viagra is effective, some men realize that it's not the magic bullet that solves their problems with intimacy, doctors said. Only about half refill their prescription.

"One has to think beyond just giving a pill to cure sexual problems," Melchiode said. "A typical example is a couple where there's been problems over the years and they can't deal with the problems on a verbal level, so they start withdrawing from one another. They build up a resentment and anger, they have trouble being close to one another and having sex with each other. Just giving them a pill isn't going to touch on all the problems of the resentment and anger."

Sex, it turns out, is part of a bigger web of relationship issues.

Morgentaler, author of "The Viagra Myth," said: "It's unrealistic that there's a pill that fixes all of these things."

2008-11-13

Mexican men 70 and older can get free Viagra

MEXICO CITY -- Mexico City is giving out free Viagra and other impotence drugs to men 70 and older. Mayor Marcelo Ebrard says the city is implementing the plan because sexuality has a lot to do with quality of life and happiness.

City Health Secretary Armando Ahued says the government will start handing out doses of one or two Viagra, Levitra or Cialis pills on December 1. They will be distributed at three centres that specialize in sexual health for the elderly.

The men will receive medical examinations before receiving the pills. Ahued says an estimated 112,000 men 70 or older live in the Federal District, which has a population of 8.7 million.

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